Yi-Tao Long selects his Editor’s Choice in analytical chemistry and sensors

Read Yi-Tao’s recent ChemSci picks covering imaging, diagnostics, phototherapy and more

Photo of Yitao Long in a circle

Professor Yi-Tao Long, Nanjing University

Professor Yi-Tao Long’s Editor’s Choice

We are delighted to share with you our latest Editor’s Choice collection that presents a selection of notable research contributions in analytical chemistry and sensors in Chemical Science from 2023 to 2024.

The featured articles selected by Chemical Science Associate Editor, Yi-Tao, demonstrate 18 cutting-edge papers in analytical chemistry and sensors, highlighting innovations in imaging, diagnostics, phototherapy, mass spectroscopy, AI-powered detection and more.

From photodynamic therapy to high-throughput proteomics, these studies showcase key advances in analytical chemistry and the creativity and interdisciplinary strength of chemical research published in Chemical Science.

 

Professor Long considers work at the forefront of analytical chemistry, including significant advances in spectroscopic analysis and electrochemistry. Submit your best manuscripts on these topics to Chemical Science for Professor Long’s consideration.

We hope you enjoy reading this selection of articles chosen by Professor Yi-Tao Long.

A mitochondria-localized iridium(III) photosensitizer for two-photon photodynamic immunotherapy against melanoma

Lili Wang, Johannes Karges, Fangmian Wei, Lina Xie, Zhuoli Chen, Gilles Gasser, Liangnian Ji and Hui Chao

Chem. Sci., 2023, 14, 1461-1471

Graphical abstract: A mitochondria-localized iridium(iii) photosensitizer for two-photon photodynamic immunotherapy against melanoma

Rational design of mesoporous chiral MOFs as reactive pockets in nanochannels for enzyme-free identification of monosaccharide enantiomers

Graphical abstract: Rational design of mesoporous chiral MOFs as reactive pockets in nanochannels for enzyme-free identification of monosaccharide enantiomers

Ligand engineering of Au44 nanoclusters for NIR-II luminescent and photoacoustic imaging-guided cancer photothermal therapy

Chem. Sci., 2023, 14, 4308-4318

Graphical abstract: Ligand engineering of Au44 nanoclusters for NIR-II luminescent and photoacoustic imaging-guided cancer photothermal therapy

Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy

Chem. Sci., 2023, 14, 2901-2909

Graphical abstract: Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy

Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells

Chem. Sci., 2023, 14, 2318-2324

Graphical abstract: Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells

The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination

Chem. Sci., 2023, 14, 2159-2167

Graphical abstract: The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination

Automatic materials characterization from infrared spectra using convolutional neural networks

Chem. Sci., 2023, 14, 3600-3609

Graphical abstract: Automatic materials characterization from infrared spectra using convolutional neural networks

Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria

Chem. Sci., 2023, 14, 4863-4871

Graphical abstract: Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria

All-in-One digital microfluidics pipeline for proteomic sample preparation and analysis

Chem. Sci., 2023, 14, 2887-2900

Graphical abstract: All-in-One digital microfluidics pipeline for proteomic sample preparation and analysis

Selective FRET nano probe based on carbon dots and naphthalimide–isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury

Chem. Sci., 2024, 15, 757-764

Graphical abstract: Selective FRET nano probe based on carbon dots and naphthalimide–isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury

Lanthanide MOF-based luminescent sensor arrays for the detection of castration-resistant prostate cancer curing drugs and biomarkers

Chem. Sci., 2024, 15, 6488-6499

Graphical abstract: Lanthanide MOF-based luminescent sensor arrays for the detection of castration-resistant prostate cancer curing drugs and biomarkers

Redox-mediated electrochemiluminescence enhancement for bead-based immunoassay

Chem. Sci., 2024, 15, 1150-1158

Graphical abstract: Redox-mediated electrochemiluminescence enhancement for bead-based immunoassay

Ratiometric near-infrared fluorescent probe for nitroreductase activity enables 3D imaging of hypoxic cells within intact tumor spheroids

Chem. Sci., 2024, 15, 3633-3639

Graphical abstract: Ratiometric near-infrared fluorescent probe for nitroreductase activity enables 3D imaging of hypoxic cells within intact tumor spheroids

Dynamic surface reconstruction of individual gold nanoclusters by using a co-reactant enables color-tunable electrochemiluminescence

Chem. Sci., 2024, 15, 3255-3261

Graphical abstract: Dynamic surface reconstruction of individual gold nanoclusters by using a co-reactant enables color-tunable electrochemiluminescence

High-throughput single-cell mass spectrometry enables metabolic network analysis by resolving phospholipid C[double bond, length as m-dash]C isomers

Chem. Sci., 2024, 15, 6314-6320

Graphical abstract: High-throughput single-cell mass spectrometry enables metabolic network analysis by resolving phospholipid C [[double bond, length as m-dash]] C isomers

High-throughput drug target discovery using a fully automated proteomics sample preparation platform

Chem. Sci., 2024, 15, 2833-2847

 

Graphical abstract: High-throughput drug target discovery using a fully automated proteomics sample preparation platform

A simplified and efficient extracellular vesicle-based proteomics strategy for early diagnosis of colorectal cancer

Chem. Sci., 2024, 15, 18419-18430

Graphical abstract: A simplified and efficient extracellular vesicle-based proteomics strategy for early diagnosis of colorectal cancer

Calibration-free reaction yield quantification by HPLC with a machine-learning model of extinction coefficients

Chem. Sci., 2024, 15, 10092-10100

Graphical abstract: Calibration-free reaction yield quantification by HPLC with a machine-learning model of extinction coefficients

 

If you are interested in research in similar areas, explore our most popular 2024 analytical chemistry articles collection and our related Imaging, biosensing and diagnostics: 2025 Chemical Science symposium collection.

Chemical Science is the flagship journal of the Royal Society of Chemistry, publishing exceptional research across the chemical sciences. As a diamond open access journal, all of our articles are free to read and free to publish – find out more and browse our latest articles on our webpage.

Keep up to date with our latest articles, reviews, collections & more by following us on Bluesky, LinkedIn or by signing up to our E-Alerts.

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Ning Jiao selects his Editor’s Choice in synthetic chemistry

Professor Ning Jiao’s Editor’s Choice

We are delighted to share with you our latest Editor’s Choice collection that presents a selection of notable research contributions in synthetic chemistry from 2023 to 2024.

The featured articles selected by Ning demonstrate significant methodological developments such as nitrogen insertion reactions for heterocycle synthesis, machine learning applications for reaction prediction, and innovative bioisostere design for drug discovery.

The collection also highlights advances in organocatalysis, photochemistry, and transition metal catalysis, covering diverse transformations such as C-H functionalization, cycloadditions, and radical reactions. Several studies focus on the synthesis of structurally complex or strained molecules, while others explore sustainable approaches under mild conditions.

These carefully selected works represent rigorous and impactful research, offering valuable insights for synthetic chemists across both fundamental and applied contexts.

Professor Jiao considers work at the forefront of synthetic chemistry, including significant advances in catalysis and organic methodology. Submit your best manuscripts on these topics to Chemical Science for Professor Jiao’s consideration.

We hope you enjoy reading this selection of articles selected by Professor Ning Jiao.

 

Nitrogen atom insertion into indenes to access isoquinolines
Patrick Finkelstein, Julia C. Reisenbauer, Bence B. Botlik, Ori Green, Andri Florin, Bill Morandi

 

On the use of real-world datasets for reaction yield prediction
Mandana Saebi, Bozhao Nan, John E. E. Herr, Jessica Wahlers, Zhichun Guo, Andrzej M. M. Zuranski, Thierry Kogej, Per-Ola Norrby, Abigail G. G. Doyle, Nitesh V. V. Chawla, Olaf Wiest

Graphical abstract: On the use of real-world datasets for reaction yield prediction

 

1,2-Disubstituted bicyclo[2.1.1]hexanes as saturated bioisosteres of ortho-substituted benzene
Aleksandr Denisenko, Pavel Garbuz, Yelyzaveta Makovetska, Oleh Shablykin, Dmytro Lesyk, Galeb Al-Maali, Rodion Korzh, Iryna V. Sadkova, Pavel K. Mykhailiuk

Graphical abstract: 1,2-Disubstituted bicyclo[2.1.1]hexanes as saturated bioisosteres of ortho-substituted benzene

 

In situ polymerization of 1,3-dioxolane and formation of fluorine/boron-rich interfaces enabled by film-forming additives for long-life lithium metal batteries
Ting Li, Kai Chen, Borui Yang, Kun Li, Bin Li, Miao He, Liu Yang, Anjun Hu, Jianping Long

Graphical abstract: In situ polymerization of 1,3-dioxolane and formation of fluorine/boron-rich interfaces enabled by film-forming additives for long-life lithium metal batteries

 

Synthesis of polysubstituted bicyclo[2.1.1]hexanes enabling access to new chemical space
Marius Reinhold, Justin Steinebach, Christopher Golz, Johannes C. L. Walker

Graphical abstract: Synthesis of polysubstituted bicyclo[2.1.1]hexanes enabling access to new chemical space

 

Lewis acid-catalyzed diastereoselective carbofunctionalization of bicyclobutanes employing naphthols
Avishek Guin, Subrata Bhattacharjee, Mahesh Singh Harariya, Akkattu T. Biju

Graphical abstract: Lewis acid-catalyzed diastereoselective carbofunctionalization of bicyclobutanes employing naphthols

 

Cobalt-catalyzed enantioselective C-H/N-H annulation of aryl sulfonamides with allenes or alkynes: facile access to C-N axially chiral sultams
Xiao-Ju Si, Xiaofang Zhao, Jianli Wang, Xinhai Wang, Yuanshuo Zhang, Dandan Yang, Mao-Ping Song, Jun-Long Niu

Graphical abstract: Cobalt-catalyzed enantioselective C–H/N–H annulation of aryl sulfonamides with allenes or alkynes: facile access to C–N axially chiral sultams

 

Lemniscular carbon nanohoops with contiguous conjugation from planar chiral [2.2]paracyclophane: influence of the regioselective synthesis on topological chirality
Jing He, Mo-Han Yu, Zhe Lian, Yan-Qing Fan, Sheng-Zhu Guo, Xiao-Nan Li, Ying Wang, Wen-Guang Wang, Zhi-Yun Cheng, Hua Jiang

Graphical abstract: Lemniscular carbon nanohoops with contiguous conjugation from planar chiral [2.2]paracyclophane: influence of the regioselective synthesis on topological chirality

 

Triarylamines as catalytic donors in light-mediated electron donor-acceptor complexes
Durbis J. Castillo-Pazos, Juan D. Lasso, Ehsan Hamzehpoor, Jorge Ramos-Sanchez, Jan Michael Salgado, Gonzalo Cosa, Dmytro F. Perepichka, Chao-Jun Li

Graphical abstract: Triarylamines as catalytic donors in light-mediated electron donor–acceptor complexes

 

Metal-free photosensitized radical relay 1,4-carboimination across two distinct olefins
Guangying Tan, Fritz Paulus, Alessia Petti, Maxim-Aleksa Wiethoff, Anna Lauer, Constantin Daniliuc, Frank Glorius

Graphical abstract: Metal-free photosensitized radical relay 1,4-carboimination across two distinct olefins

 

2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants
Shashwati Paul, Daniel Adelfinsky, Christophe Salome, Thomas Fessard, M. Kevin Brown

Graphical abstract: 2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants

 

Transition metal-free photochemical C-F activation for the preparation of difluorinated-oxindole derivatives
Bianca Matsuo, Jadab Majhi, Albert Granados, Mohammed Sharique, Robert T. Martin, Osvaldo Gutierrez, Gary A. Molander

Graphical abstract: Transition metal-free photochemical C–F activation for the preparation of difluorinated-oxindole derivatives

 

Stereoselective alkyl C-glycosylation of glycosyl esters via anomeric C-O bond homolysis: efficient access to C-glycosyl amino acids and C-glycosyl peptides
Anrong Chen, Shiyin Zhao, Yang Han, Zhenghong Zhou, Bo Yang, Lan-Gui Xie, Maciej A. Walczak, Feng Zhu

Graphical abstract: Stereoselective alkyl C-glycosylation of glycosyl esters via anomeric C–O bond homolysis: efficient access to C-glycosyl amino acids and C-glycosyl peptides

 

Lewis acid catalyzed [4+2] annulation of bicyclobutanes with dienol ethers for the synthesis of bicyclo[4.1.1]octanes
Stefano Nicolai, Jerome Waser

Graphical abstract: Lewis acid catalyzed [4+2] annulation of bicyclobutanes with dienol ethers for the synthesis of bicyclo[4.1.1]octanes

 

Palladium-catalyzed decarboxylative (4+3) cycloadditions of bicyclobutanes with 2-alkylidenetrimethylene carbonates for the synthesis of 2-oxabicyclo[4.1.1]octanes
Xin-Yu Gao, Lei Tang, Xu Zhang, Jian-Jun Feng

Graphical abstract: Palladium-catalyzed decarboxylative (4 + 3) cycloadditions of bicyclobutanes with 2-alkylidenetrimethylene carbonates for the synthesis of 2-oxabicyclo[4.1.1]octanes

 

Visible-light-driven alkene dicarboxylation with formate and CO2 under mild conditions
Fulin Zhang, Xiao-Yang Wu, Pan-Pan Gao, Hao Zhang, Zhu Li, Shangde Ai, Gang Li

Graphical abstract: Visible-light-driven alkene dicarboxylation with formate and CO2 under mild conditions

 

One-pot asymmetric living copolymerization-induced chiral self-assemblies and circularly polarized luminescence
Run-Tan Gao, Shi-Yi Li, Bing-Hao Liu, Zheng Chen, Na Liu, Li Zhou, Zong-Quan Wu

Graphical abstract: One-pot asymmetric living copolymerization-induced chiral self-assemblies and circularly polarized luminescence

 

De novo synthesis of inherently chiral heteracalix[4]aromatics from enantioselective macrocyclization enabled by chiral phosphoric acid-catalyzed intramolecular SNAr reaction
Xing-Chi Li, Ying Cheng, Xu-Dong Wang, Shuo Tong, Mei-Xiang Wang

Graphical abstract: De novo synthesis of inherently chiral heteracalix[4]aromatics from enantioselective macrocyclization enabled by chiral phosphoric acid-catalyzed intramolecular SNAr reaction

 

If you are interested in similar areas, explore our most popular organic and catalysis themed collections!

Chemical Science is the flagship journal of the Royal Society of Chemistry, publishing exceptional research across the chemical sciences. As a diamond open access journal, all of our articles are free to read and free to publish – find out more and browse our latest articles on our webpage.

Keep up to date with our latest articles, reviews, collections & more by following us on Bluesky, LinkedIn or by signing up to our E-Alerts.

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2025 Chemical Science Lectureship awarded to Chris Chang

Awarded for contributions to the field of imaging chemistry, biosensing and diagnostics

Chemical Science is delighted to announce the winner of our 2025 Lectureship, Professor Christopher Chang!

Launched in our 15th anniversary year, the Chemical Science Lectureship celebrates leading, independent researchers at all career stages who have made exceptional discoveries and innovations in their field within the last five years. This annual lectureship focuses on a specific subject area that aligns with the Chemical Science symposium each year, rotating to cover the breadth of the journal and all areas of the chemical sciences.

This year, the Lectureship focused on the chemistry of imaging, biosensing and diagnostics and Professor Chris Chang was selected as the winner for his recent research on activity-based sensing and transition metal signalling. Chris will deliver the Lectureship at the 2025 Chemical Science Symposium on the same theme on 18-19 November in London, UK.

About our 2025 winner:

Photograph of Chris Chang, by David Kelly CrowChristopher Chang, Princeton University

Chris Chang is the Edward and Virginia Taylor Professor of Bioorganic Chemistry at Princeton University. He completed his B.S. and M.S. degrees from Caltech in 1997 with Harry Gray, a Fulbright scholarship with Jean-Pierre Sauvage, a Ph.D. from MIT in 2002 with Dan Nocera, and a postdoc at MIT with Steve Lippard. Chris started his independent career at UC Berkeley in 2004 before moving to Princeton in 2024.

The Chang laboratory studies the chemistry and biology of the elements. His group has pioneered the concept of activity-based sensing, showing that selectivity in sensor design is achievable by reaction-based methods that go beyond traditional binding-based approaches that operate by lock-and-key molecular recognition.

Christopher’s work has also changed dogma in the inorganic and chemical biology communities by showing that transition metals are not merely active site cofactors in proteins but also serve as dynamic transition metal signals that operate as allosteric regulators of protein function through metalloallostery, giving rise to new metal-dependent cell growth and proliferation pathways such as cuproplasia and ferroplasia.

He has mentored nearly 150 graduate, postdoc, and undergraduate researchers, with 46 alumni who are now faculty leading their own laboratories. He currently serves as Editor-in-Chief for Accounts of Chemical Research.

Read Chris’ recent Chemical Science articles:

A mitochondrial-targeted activity-based sensing probe for ratiometric imaging of formaldehyde reveals key regulators of the mitochondrial one-carbon pool
Logan Tenney, Vanha N. Pham, Thomas F. Brewer and Christopher J. Chang*
Chem. Sci., 2024, 15, 8080-8088

A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells
Zeming Wang, Tyler C. Detomasi and Christopher J. Chang
Chem. Sci., 2021, 12, 1720-1729

 

Find out more about the 2025 Chemical Science Symposium on the chemistry of imaging, biosensing and diagnostics where Chris will deliver the 2025 Lectureship on our event webpage.

Promotional banner for symposium, with graphical background image relating to imaging chemistry

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Chemical Science Reviewer Spotlight – June 2025

Chemical Science Reviewer Spotlight – June 2025

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Dr Stephen Fielden, Dr Franziska Thomas, Professor Luca Dell’Amico and Professor Xin-Yao Yu. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

 

Dr Stephen Fielden, University of Birmingham

 

Dr Stephen Fielden, University of Birmingham. I combine supramolecular chemistry and polymer science to develop new nanotechnology. I am particularly interested in developing complex systems of nanoparticles that influence and control each other.

 

Dr Franziska Thomas, Heidelberg University

 

Dr Franziska Thomas, Heidelberg University. My research focuses on designing and synthesising functional miniproteins — peptides with a defined three-dimensional structure that can contain natural and non-natural building blocks.

 

Professor Luca Dell’Amico, University of Padova

 

Professor Luca Dell’Amico, University of Padova. We build molecules using the most sustainable methods available or developing new ones. We harness the transformative power of light, either by directly exciting the molecules or by employing organic photocatalysts. We are fascinated by new reaction manifolds that open up novel pathways to access previously unattainable scaffolds and bioactive molecules. We study these new synthetic transformations in depth using a range of optical and spectroscopic techniques, as well as computational methods.

 

Professor Xin-Yao Yu, Anhui University

 

Professor Xin-Yao Yu, Anhui University. My research centers on the design and synthesis of advanced materials for energy storage and conversion.

 

What encouraged you to review for Chemical Science?

Dr Stephen Fielden: I know that a paper considered for Chemical Science is going to contain exciting new results and provide a scientific advance that I haven’t seen before. Also, I like to help the RSC to continue publishing impactful work in an open access format.

Dr Franziska Thomas: Chemical Science is an interdisciplinary journal that I regularly read and in which I have also published articles. As my own manuscripts have been reviewed by other scientists, I consider it my duty to review manuscripts in return.

Professor Luca Dell’Amico: Chemical Science is a go-to journal for us chemists. It always maintains excellent research standards, which motivates me to do my best as a reviewer and contribute to its continued growth.

Professor Xin-Yao Yu: I was motivated by the journal’s reputation for publishing high-impact, interdisciplinary chemical research, coupled with its commitment to rigorous yet constructive peer review. As a researcher in materials chemistry, I see reviewing as a way to contribute to maintaining scientific standards while engaging with cutting-edge work in my field.

 

What do you enjoy most about reviewing?

Dr Stephen Fielden: I really enjoy being one of the first people to see new science. In addition, it’s satisfying to know that I can help ensure that new advances are impactful as possible.

Dr Franziska Thomas: It is always nice to read about new and refreshing concepts. What I enjoy most is offering my colleagues suggestions on how to improve a manuscript, thereby enhancing the research it describes.

Professor Luca Dell’Amico: It’s when I see exciting new findings and the authors’ enthusiasm, combined with a detailed and precise analysis of new reaction manifolds and/or applications, that I feel truly inspired.

Professor Xin-Yao Yu: The most rewarding aspect of reviewing is the opportunity to engage with innovative research at the forefront of the field. I enjoy critically evaluating scientific arguments, identifying strengths that deserve recognition, and providing constructive feedback to help authors refine their work. Additionally, reviewing allows me to learn from diverse research approaches and gain fresh perspectives that often inspire new ideas in my own work.

 

What are you looking for in a paper that you can recommend for acceptance in Chemical Science?

Dr Stephen Fielden: I am looking for a new concept that draws together disparate areas of research. If the science has been done well to evidence the claims behind this new concept then I am happy.

 

What makes a paper truly stand out for you when reviewing a paper?

Dr Franziska Thomas: An exceptional manuscript is characterised by an innovative research idea that is systematically implemented through a series of well-founded experiments. Additionally, an outstanding publication is supported by figures and schemes that convey the research results clearly, even when the text is not read.

Professor Luca Dell’Amico: As mentioned above, I believe it’s a combination of the authors’ enthusiasm in presenting their findings and the deep mechanistic understanding of a new process or mechanism with broader applications.

 

What single piece of advice would you give to someone about to write their first review?

Dr Franziska Thomas: Read the manuscript through once, then put it aside for a day before reading it again in detail. Don’t forget to read the supplementary material.

 

How has your approach to peer reviewing changed over time?

Professor Luca Dell’Amico: I always follow the same approach: first, a general read-through, and then a more detailed understanding of the work by going section by section, also analyzing the supporting materials. Sometimes we’re overwhelmed with review requests, but I always stick to this method—perhaps being a bit late at times—in order to maintain the highest possible standards. We owe this to both the authors (as fellow researchers) and to the journal.

 

What advice would you give a first-time author looking to maximise their chances of successful peer review?

Professor Xin-Yao Yu: Clarify the scientific significance; clearly articulate how the work addresses a critical challenge in the field and why it matters beyond the specific methodology. Prioritize logical flow; organize the manuscript with a strong narrative structure, ensuring each section (introduction, methods, results, discussion) builds coherently toward the central conclusion. Anticipate reviewer concerns; proactively address potential limitations, compare your work with existing literature, and provide robust data to support claims. Pay attention to presentation; use high-quality figures and concise language to enhance readability.

 

What has been your biggest learning point from reviewing?

Dr Stephen Fielden: Insight into the peer review process is essential for scientists to learn their craft and to see that every good research paper starts as a ‘rough diamond’.

 

Did reviewing for Chemical Science affect how you approached preparation of your recent publication with us?

Professor Xin-Yao Yu: Yes, the reviewing experience has significantly influenced my approach to manuscript preparation for Chemical Science. Through evaluating other researchers’ work, I gained a deeper understanding of the journal’s expectations for novelty, rigor, and interdisciplinary appeal. This perspective helped me refine the narrative of our recent submission, ensuring we emphasized the broader implications of our findings and proactively addressed potential cross-disciplinary questions. Additionally, reviewing highlighted the importance of clear data presentation and robust supporting information, which we prioritized in our manuscript to enhance transparency and scientific integrity.

 

Tune in soon to meet our next group of #ChemSciReviewers!

 

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Most popular 2024 article collections

Find out more about our most popular 2024 article collections across all areas of the chemical sciences.

Here at Chemical Science, we are pleased to share subject-specific collections of our most popular Chemical Science content published in the last year. These collections are designed to highlight some of the exceptional research published in Chemical Science – and like all Chemical Science articles, they are free to access and read from anywhere in the world with no restrictions.

We hope you enjoy reading our selections of 2024 most popular articles in the collections below.

Analytical Chemistry

Featuring nanotechnology and molecular imaging, revolutionizing diagnostics, therapy, real-time biological monitoring and more.

 

Energy & Environment

Including work on perovskite solar cells, supercapacitors, materials for different types of batteries, plastic recycling and more.

 

Physical & Theoretical Chemistry

Ranging from insights into delocalization errors within the density-functional many-body expansion to visible-light-driven stiff-stilbene photoswitches.

Catalysis

Including articles on photocatalytic plastic upcycling, switchable molecular electrocatalysis and much more.

 

Materials Chemistry

Ranging from recent advances in phosphorescent and fluorescent organic materials, non-linear optical materials, advances in MOFs, HOFs, and porous cages, organic photoswitches, and many other topics.

 

Inorganic Chemistry

Ranging from optical fluoride materials to insights into [FeFe] hydrogenases.

Chemical Biology

Featuring photodynamic therapy, polypeptide folding, and much more.

 

Supramolecular & Polymers Chemistry

Including polymer and supramolecular synthesis, recycling strategies, biomedical and catalytic applications and more.

 

Organic Chemistry

Featuring peptide macrocyclisation, coupling reactions, continuous flow synthesis, and much more.

 

Be sure to also browse our most popular all time article collection we have specially selected for our 15th anniversary in 2025 and find out more in our blog post.

 

Chemical science logo

 

Submit to Chemical Science today! Check out our author guidelines for information on our article types and find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on social media (BlueSky, LinkedIn, Facebook, X), and browse the articles in our latest issues by signing up to our E-Alerts.

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Chemical Science Reviewer Spotlight – March 2025

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Dr Ana Bahamonde, Professor Andrew Sue and Dr Felix Plasser. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Dr Ana Bahamonde, University of California Riverside. Our group focuses on advancing the understanding of Ni catalysis, specifically addressing its tendency to alternate between 1- and 2-electron mechanisms. Our goal is to achieve a deep enough understanding of what drives each reaction pathway, enabling us to leverage this knowledge to improve existing catalytic systems.

 

Professor Andrew Sue, Xiamen University. Our research group utilizes dynamic covalent chemistry and coordination-driven assembly to construct nanotubular cavitand hosts, exploring molecular recognition and behavior within these confined spaces.

 

Dr Felix Plasser, Loughborough University. My research is in computational photochemistry. We use computer simulations to learn how molecules interact with light to aid in the design of next-generation materials.

 

What encouraged you to review for Chemical Science?

Professor Andrew Sue: My very first research paper during my PhD was published in Chemical Science, making it a journal that holds a special place in my heart.

Dr Felix Plasser: I believe that reviewing is an important part of the scientific process. When I was first asked to review, I was also somewhat honoured that Chemical Science put their trust in me as a reviewer.

Dr Ana Bahamonde: When reviewing a paper, I invest significantly more effort in critically evaluating every hypothesis and explanation compared to when I read general literature. This approach helps me explore different perspectives and learn from others.

 

What do you enjoy most about reviewing?

Dr Ana Bahamonde: What I enjoy most is that, every now and then, I get the opportunity to help authors refine their findings or delivery.

Professor Andrew Sue: I am motivated by the opportunity to engage with novel research firsthand, gaining early insights before they become publicly available. I also appreciate the chance to contribute to shaping these papers and ensuring their quality and impact.

Dr Felix Plasser: I enjoy having a chance to shape the work that is being published and to provide a critical assessment of the underlying methods. Reviewing also provides a great chance for staying up to date with current research in my area.

 

Do you have any advice to our readers seeking publication in Chemical Science on what makes a good paper?

Dr Ana Bahamonde: I believe a good paper offers a novel solution to an unresolved problem. It is crucial to clearly emphasize the paper’s originality and the specific outstanding issue it addresses in the introduction.

 

What advice would you give a first-time author looking to maximise their chances of successful peer review?

Dr Felix Plasser: Make sure to take all reviewer comments seriously. Even if you are frustrated that the reviewer does not get your point, act on their comments. You can assume that readers won’t get your point either – so try to improve your paper rather than arguing with the reviewers.

 

What are you looking for in a paper that you can recommend for acceptance in Chemical Science?

Professor Andrew Sue: I look for papers that present brilliant ideas backed by rigorous execution, along with an effective and scholarly presentation. Additionally, I highly value unexpected, serendipitous discoveries that provide fresh insights and have the potential to inspire new directions in research.

 

Tune in soon to meet our next group of #ChemSciReviewers!

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Chemical Science Reviewer Spotlight – November 2024

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Professor Amy Fraley, Professor Knut Asmis, Dr Chidambar Kulkarni and Professor Mark MacLachlan. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Professor Amy Fraley, ETH Zürich. Our group approaches medicinal chemistry from a non-traditional angle, taking inspiration from nature, and tuning natural systems (for example enzymes and even whole organisms) towards challenges impacting human health or the environment.

 

Professor Knut Asmis, Universität Leipzig. Our group characterizes the intrinsic properties of molecules, clusters and nanoparticles in order to gain a deeper understanding on how these can be affected by their environment.

 

Dr Chidambar Kulkarni, IIT Bombay. Our research involves the design, synthesis and understanding the mesoscopic assembly of functional organic molecules/polymers to ultimately gain control over the macroscopic devices made up of these materials. We use a physical-organic chemistry approach to gain insights into soft functional materials.

 

Professor Mark MacLachlan, The University of British Columbia. Our group makes new molecules and materials that have interesting structures and stretch our chemical creativity. We are especially interested in new substances with interesting optical properties that can make them useful for sensing.

 

What encouraged you to review for Chemical Science?

Professor Amy Fraley:  I was motivated to review for Chemical Science due to the breadth of interdisciplinary work that they foster. I enjoy contributing feedback and giving back to the community, especially when these efforts are toward a journal offering to make peer-reviewed articles freely and permanently available online such as the Diamond Open Access program offered by Chemical Science.

Dr Chidambar Kulkarni: Chemical science is one of my frequently read general chemistry journals, contributing to this community at large by reviewing is an honour. 

Professor Knut Asmis: Reviewing is part of my community duty and since Chemical Science is one of the few outstanding and interdisciplinary journals I particularly enjoy to review for them. 

Professor Mark MacLachlan: I have been asked to review several papers for Chemical Science.  As I like the journal and publish there, I feel a responsibility to occasionally review manuscripts for the journal.  I find the papers are generally high quality and of interest to me.

 

What do you enjoy most about reviewing?

Professor Amy Fraley: I like that reviewing provides me with the opportunity to read about the latest discoveries in my field, and contribute my thoughts to constructively shape the work in its final published form.

Dr Chidambar Kulkarni: The fact that I get to view a new piece of science for the first time and help improve it is enjoyable.

Professor Knut Asmis: Learning how others do research, what research topics they work on and how they place their research results in a more general context. 

Professor Mark MacLachlan: I like to review papers as a way to keep up on the literature – even before the work is published.

 

What are you looking for in a paper that you can recommend for acceptance in Chemical Science?

Professor Amy Fraley: I look for innovative work that presents groundbreaking discoveries in the field, but also recognizes the foundational work that came before. The authors should be able to place their discoveries in the context of related research, and describe what makes their work stand out.

Dr Chidambar Kulkarni: I look for either a conceptual advancement or new materials with appealing properties or novel insights into existing systems.

Professor Knut Asmis: Insights into chemistry, based on state-of-the-art research approaches that yield high quality data that is presented in a clear form and from which concise conclusions can be derived, that go beyond the borders of a particular discipline. 

Professor Mark MacLachlan: I am looking for a paper that is easy to read and understand, reports something new, and has results that are either surprising or significant.  My favourite papers to review usually involve an element of serendipity – an unexpected crystal structure, reaction, or effect – or achieving something challenging.

 

What would you recommend to new reviewers to ensure their report is helpful?

Professor Knut Asmis: Think twice, before accepting to review a particular manuscript. Identify weak spots and suggest improvements. Don’t get lost in detail. Treat the authors as you would like to be treated.   

 

Tune in next month to meet our next group of #ChemSciReviewers!

 

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Chemical Science Reviewer Spotlight October 2024

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Dr Alexa Kuenstler, Dr John Mack, Professor AnnMarie O’Donoghue and Professor Nathalie Steunou. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Dr Alexa Kuenstler, University of Illinois Urbana-Champaign (USA).  My group works at the intersection of polymer chemistry and polymer physics to develop soft materials that address challenges in sustainability, energy, and human health.

 

Dr John Mack, Rhodes University (South Africa). I use molecular modelling to guide the rational selection of porphyrins and their analogues for applications, often in the context of their nanoparticle conjugates. The applications include use as photosensitizer dyes in photodynamic therapy against cancer cells and antibiotic-resistant bacterial strains, and as optical limiting materials for attenuating intense incident laser pulses.

 

Professor AnnMarie O’Donoghue, Durham University (United Kingdom). I am a physical organic chemist focused on the detailed understanding of reaction mechanism in organo- and enzymatic catalysis. Following decades of impressive developments and identification of many new catalysts, I strongly believe that further progress will depend on in-depth understanding of mechanism and is particularly important in addressing sustainability goals.

 

Professor Nathalie Steunou, Université de Versailles – Saint-Quentin-en-Yvelines (France). The research of Nathalie Steunou is focused on the design of hybrid inorganic-organic materials including MOFs and composites for energy, health and environment related applications.

 

 

What encouraged you to review for Chemical Science?

Dr Alexa Kuenstler: Chemical Science publishes work at interdisciplinary interfaces – I both value this scientific ethos and appreciate the opportunity to serve the greater scientific community.

Dr John Mack: The very high quality of this journal means that almost all manuscripts sent out for review are likely to be on the cutting edge in terms of the fields I am involved in.

Professor AnnMarie O’Donoghue: Chemical Science is one of the flagship international RSC journals. It is good to support both the journal and the chemistry field more widely through provision of reviews.

Professor Nathalie Steunou: Reviewing articles is one of the scientific activities a researcher must carry out, and it’s always very interesting to read articles covering interdisciplinary topics in chemistry and materials science and to have the opportunity to exchange scientific views with the authors.

 

What do you enjoy most about reviewing?

Dr Alexa Kuenstler: I enjoy the opportunity to engage with cutting-edge work that is cross-disciplinary.

Dr John Mack: Although it can be time-consuming at times, it does provide an opportunity to stay current on how a broader scientific field is developing with regards to what experiments are possible with regards to the characterization of compounds and the analysis of their properties and utility for applications while providing a service to the broader scientific community as part of the basic obligations of being an academic.

Professor AnnMarie O’Donoghue: I enjoy the insights provided of current state-of-the-art developments and concepts in chemistry. I also learn from the different presentation styles of Chemical Science authors. I am always impressed by the creative graphics included by authors!

Professor Nathalie Steunou: It’s very important to read the recent works submitted by my scientific community and to keep abreast of scientific advances. It’s also a time for scientific exchanges and, of course, a time for reflection on one’s own work.

 

What advice would you give a first-time author looking to maximise their chances of successful peer review?

Dr Alexa Kuenstler: Good papers tell good stories – use compelling figures to present interesting data and use the text to place these into the broader context of the work. Above all, make sure the work teaches the community something!

Dr John Mack: It is extremely important to master how to use software such as Excel and Powerpoint to present their data sets as clearly as possible to the reviewer.

What makes a paper truly stand out for you when reviewing a paper?

Professor AnnMarie O’Donoghue: It can be difficult to give the necessary time to providing detailed, constructive, balanced reviews as we are all time-pressed, however, it is one of the most important contributions we can make to the community. Particularly for Early Career Researchers, I think it is very important to maintain a positive, constructive tone and highlight positive aspects of a manuscript in addition to potential areas for improvement.

 

Do you have any advice to our readers seeking publication in Chemical Science on what makes a good paper?

Professor Nathalie Steunou: I don’t have any advice to give, just an opinion. To write a good article is to concisely tell a creative scientific story and, as a result, send a message that is likely to be of interest to the entire chemistry community.

 

Are there any steps that reviewers can undertake to improve the quality of their review?

Dr John Mack: I think it is important to avoid only being harshly negative when it becomes necessary to outright reject a paper. Time should be taken to leave the corresponding author with a clear picture of what you think they will need to do in future to reach the level that they aspire to.

Professor AnnMarie O’Donoghue: It can be difficult to give the necessary time to providing detailed, constructive, balanced reviews as we are all time-pressed, however, it is one of the most important contributions we can make to the community. Particularly for Early Career Researchers, I think it is very important to maintain a positive, constructive tone and highlight positive aspects of a manuscript in addition to potential areas for improvement.

 

Did reviewing for Chemical Science affect how you approached preparation of your recent publication with us?

Professor Nathalie Steunou: Writing a really good article isn’t easy, and you learn a lot about writing by reading and assessing the work of others.

 

Tune in next month to meet our next group of #ChemSciReviewers!

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Chemical Science Reviewer Spotlight – September 2024

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Professor Kevin Huang and Professor Fei Li. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Professor Fei Li, Xi’an Jiaotong University (China). My present research interests are development and applications of various electroanalytical methods and techniques in biomedical engineering studies, including single-cell electrochemical analysis and point-of-care testing electrochemical biosensors.

Professor Kevin Huang, University of South Carolina (USA). My research is on electrochemical materials and devices.

 

What encouraged you to review for Chemical Science?

Professor Fei Li: The reputation, quality and broad areas of Chemical Science. 

Professor Kevin Huang: Desire to learn and judge new advancements in basic science.

What do you enjoy most about reviewing?

Professor Fei Li: The most up-to-date researches and the different ways that authors tell their stories. 

Professor Kevin Huang: Learning new knowledge and getting to know the most recent developments.

Do you have any advice to our readers seeking publication in Chemical Science on what makes a good paper?

Professor Kevin Huang: Focusing on presenting your own understanding on fundamental aspects of new discoveries.

What are you looking for in a paper that you can recommend for acceptance in Chemical Science?

Professor Fei Li: The novelty and uniqueness, the systematic and solid experiments, as well as the contribution to the corresponding research areas and even the whole chemistry field.

 

Tune in next month to meet our next group of #ChemSciReviewers!

 

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Chemical Science Reviewer Spotlight – August 2024

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Professor Liliya Yatsunyk, Dr Hajime Kameo and Dr Amar Flood. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Professor Liliya Yatsunyk, Swarthmore College (USA). Canonical DNA is well known as a carrier of genetic information. But non-canonical DNA structures that my lab investigates play functional roles in our bodies, regulating a variety of important biological processes, notably cancer and aging.

 

Dr Hajime Kameo, Osaka Prefecture University, Japan. My research focuses on contributing to the deepening of catalysis science based on the chemistry of organometallic complexes.

 

Dr Amar Flood, Indiana University (USA). Amar studies ion-driven assembly with an emphasis on what anions bring to the table for molecular recognition and self-assembly leading to responsive polymers and optical materials (called SMILES).

 

What encouraged you to review for Chemical Science?

Professor Liliya Yatsunyk: Being a reviewer is a great privilege as it gives me a chance to glimpse into the newest research findings. It also gives me an opportunity to shape this research with my careful feedback on the submitted work.

Dr Amar Flood: The journal attracts interesting chemistry-focussed research, and so the articles are fun and enjoyable to read and review.

Dr Hajime Kameo: Chemical Science is one of my favorite journals and makes a significant contribution to the chemical community. Its high quality is indicative of a rigorous and fair peer review process. I am honored to be a part of this process.

 

What do you enjoy most about reviewing?

Professor Liliya Yatsunyk: Learning new things, helping others to improve their work, and feeling part of the great community of scientists.

Dr Amar Flood: Helping the authors (and particularly the first author) to improve the quality of the science and its communication to the community

Dr Hajime Kameo: Aside from being able to contribute to the scientific community at a high level, the most enjoyable part is the opportunity to reaffirm my interest in chemistry by reading stories of cutting-edge, outstanding chemistry.

 

Do you have any advice to our readers seeking publication in Chemical Science on what makes a good paper?

Dr Hajime Kameo: The significance and value of the study are clearly demonstrated through concise text and attractive figures and tables.

 

Are there any steps that reviewers can undertake to improve the quality of their review?

Professor Liliya Yatsunyk: Do not stretch themselves thin with taking on too many papers to review or having other commitments. Also, as a reviewer, one needs to keep in mind that our task is not to criticize the authors or find mistakes, our task is to help authors improve their work – shape your review with that goal in mind. Focus on the big picture and major problems that you see with the review – word editing is not a reviewer’s job and it takes lots of time and potentially also detracts from delivering the useful message.

 

Tune in next month to meet our next group of #ChemSciReviewers!

 

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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